Anna Zee, the four-time winner of the National Music Director of The Year (medium market) award [citation needed], is heard in mid-days.

Afternoon drive time features Tom Bedell (who is also host of The Q 104 Early Dismissal, the 5 O'Clock Traffic Jam, and the award-winning local music program Route 104).

The station's original line-up consisted of the "Morning Zoo" with Brother Jake Edwards, Hal Harbour (Doug Barron), and "Billy-Bob" (Bill Phillips), mid-days with "The Legend" Bob Powers, afternoon drive with Andy K., six-o'clock rock report with "Rockin'" Ray Plourde, as well as the Midnight Metal Show and weekend afternoons with Jessica Taylor who also created and did the voice of Bambi Fawn from the morning shows sponsored "Between the Sheets".

CFRQ's evening program "The Rock of The Atlantic" (taking its name from the station's original slogan), airing weeknights from 7pm to 12am, was launched in August 2016 and simulcasts on CKEZ-FM New Glasgow, CJMO-FM Moncton and CHNI-FM Saint John.

Annual charitable initiatives include "The Q104 Hunger Strike" (2006–2018) assisting Feed Nova Scotia and the Q104 Thanksgiv'er, which was started in 2019.