The arena hosts basketball and hockey games, professional wrestling events, concerts, and the annual shareholders' meeting of Omaha-based conglomerate Berkshire Hathaway, usually held on the first Saturday of May.

Qwest Center Omaha opened in September 2003 with an initial seating capacity of 17,000 for concerts, 15,500 for basketball, and 14,700 for hockey.

The Qwest Center displaced the 1954 Omaha Civic Auditorium as the city's premier indoor arena.

The arena has also hosted six championship boxing cards, all involving Omaha native Terence Crawford as he wanted to defend his titles in front of a home crowd.

The arena hosts the Nebraska School Activities Association state wrestling championships each February.

[10] The Omaha Fire Department pumped in 2 million U.S. gallons (7,600 cubic meters) of water from hydrants around the center.

[17] and the 2021 pool going to a group in Minneapolis, Minnesota that plans to convert an abandoned book bindery in the city's Near North neighborhood into an Olympic-caliber aquatic center.

In 2006, the MCEA funded a project to expand the arena and add an additional 1,472 seats to the upper bowl.

[22] The project also included adding restroom facilities and concession stands, as well as updating aesthetics, mechanical systems, and emergency exits.

Built in 2001, the arena was meant to replace the aging Omaha Civic Auditorium and demolished Ak-Sar-Ben Coliseum.

[37] CHI Health Center holds several NCAA attendance records, particularly in women's college volleyball.

This broke a record set two days earlier, when Nebraska defeated another former conference rival, Kansas, in the national semifinals in front of a crowd of 17,551.