The first cases of the COVID-19 pandemic of Coronavirus Disease 2019 in North America were reported in the United States on 23 January 2020.

[2] On 26 March 2020, the United States became the country in North America with the highest number of confirmed COVID-19 infections, at over 82,000 cases.

[103] On 17 December 2020, Mercer University pre-med student Skylar Mack, 18, from United States, and her boyfriend Vanjae Ramgeet, 24, of the Cayman Islands, were sentenced to four months in prison for her violating the island's mandatory two-week quarantine two days after arriving from the United States, and for his aiding and abetting her.

[93] The COVID-19 pandemic was confirmed to have reached the British Overseas Territory of the Turks and Caicos Islands on 23 March 2020.

[93] The virus was confirmed to have reached Canada on January 25, 2020, after an individual who had returned to Toronto from Wuhan, Hubei, China, tested positive.

[115] In March 2020, as cases of community transmission were confirmed, all of Canada's provinces and territories declared states of emergency.

Canada severely restricted its border access, barring travelers from all countries with some exceptions.

The federal Minister of Health invoked the Quarantine Act, introduced following the 2002–2004 SARS outbreak.

Cuba's death toll of 324 is well under the world average per capita, but health authorities worry that it is increasing.

[97] The COVID-19 pandemic was confirmed to have spread to Greenland – an autonomous territory of the Kingdom of Denmark – in March 2020.

[93] On 13 March 2020, Prime Minister Evelyn Wever-Croes announced the first two confirmed cases of coronavirus on the island.

[153][non-primary source needed] The COVID-19 pandemic was confirmed to have reached El Salvador on 18 March 2020.

They then returned to Sint Maarten and were detected at the airport and transferred to French Saint Martin hospital for isolation.

[158] The COVID-19 pandemic was confirmed to have spread to the French overseas department and region of Guadeloupe on 12 March 2020.

[93] The COVID-19 pandemic was confirmed to have reached the French overseas department and region of Martinique on 5 March 2020.

[93] The COVID-19 pandemic was confirmed to have reached the French overseas collectivity of Saint Barthélemy on 1 March 2020.

[93] The COVID-19 pandemic was confirmed to have reached the French overseas collectivity of Saint Pierre and Miquelon on 5 April 2020.

[171] 28-year-old nursing student Keyla Patricia Martínez was arrested in La Esperanza, Intibucá Department and was murdered by choking while in police custody.

All people entering Jamaica from China will be subject to immediate quarantine for at least 14 days, and anyone who was allowed to land and shows symptoms of the virus will be put in immediate isolation.

[175] In keeping with the new policy, 19 Chinese nationals who arrived at the Norman Manley International Airport on the evening of 31 January 2020 were denied entry, quarantined and put on a flight back to China on 1 February.

[177] On 11 March 2020, the country's health minister confirmed the second "imported corona virus [sic]" case.

[93] The Panamanian government has enhanced its sanitary control and screening measures at all ports of entry, to prevent the spread of the virus, isolating and testing potential cases.

[185] On 9 March 2020, the health ministry (MINSA) announced Panama's first coronavirus case, a Panamanian woman in her 40s who had returned from Spain.

[191] On 17 March governor Wanda Vázquez Garced announced a 24/7 lockdown, with people only allowed to leave their homes for food, gas or medicines.

[206] On 26 March 2020, the United States surpassed China and Italy as the country with the most confirmed COVID-19 cases, with a figure above 82,000.

[207][208] The U.S. federal government's health inspectors surveyed 323 hospitals in late March; reporting "severe shortages" of test supplies, "widespread shortages" of personal protective equipment (PPE), and other strained resources due to extended patient stays while awaiting test results.

[209] On 11 April 2020, the United States surpassed Italy as the country with the most confirmed COVID-19 deaths, with a total of over 20,000.

[212] By 20 April 2020, the federal government stated it was conducting 150,000 tests per day, and claimed that this number would be enough to allow for schools and businesses to reopen.

Health experts estimate that 500,000 to 1,000,000 tests per day would be needed to properly track the spread of the COVID-19, to avoid a new wave of infections.

[216] On 11 December 2020, the United States Food and Drug Administration (FDA) authorized for the emergency use of the Pfizer-BioNTech COVID-19 vaccine.