[5] On 24 December 2020, the Expert Committee submitted its recommendations on the overall vaccination strategy of Singapore to the government.

[17] On 3 February 2021, Singapore also became the first country in Asia to approve Moderna's COVID-19 vaccine, jointly developed by the National Institute of Allergy and Infectious Diseases (NIAID), the Biomedical Advanced Research and Development Authority (BARDA), and Moderna.

It was granted interim authorization by the HSA under the Pandemic Special Access Route in December 2020.

[21][26][27] On 24 June, the Health Ministry concluded a purchase agreement with Novavax for its non-mRNA COVID-19 vaccine, with shipments expected to arrive in Singapore before the end of 2021.

[28] On 28 July, IHH Healthcare Singapore obtained approval to import the Sinopharm BIBP vaccine (BBIBP-CorV) via the special access route (SAR).

[34] On 10 December, the Health Sciences Authority approved the use of the Pfizer-BioNTech coronavirus vaccine for children aged 5 to 11 with the first shots to be given by end-2021.

Singapore started the rolling out of booster shots for senior citizens above 60 years of age from 14 September 2021.

[38] From 24 November, eligible population who completed their second dose before 5 months can get booster shots for all age groups.

On 14 February 2022, the Health Sciences Authority (HSA) announced that it had granted interim authorization for the Novavax vaccine under the brand name Nuvaxovid, under the Pandemic Special Access Route; it is a two-dose regimen, and shall be included in the National Vaccination Programme for adults aged 18 years old and above.

[45] On 24 September 2021, Malaysian National Recovery Council chairman Muhyiddin Yassin confirmed that Malaysia and Singapore would recognise each other's vaccination certificates in order to facilitate travel between the two countries.