The Betway T20 Challenge is a domestic Twenty20 Cricket competition in South Africa, first contested in the 2003–04 season.

The current champions are the Imperial Lions, whilst the Titans have been the most successful with 6 title wins.

The tournament has been contested since its inception by the six franchise teams but for the 2007–08 season, Zimbabwe took part as a seventh side.

The tournament was however played during February 2021, with all the matches taking place at the Kingsmead Cricket Ground in Durban.

It replaced the 2020 edition of the Mzansi Super League, which was cancelled due to the COVID-19 pandemic.