William Petersen and Jorja Fox reprised their roles from CSI: Crime Scene Investigation as Gil Grissom and Sara Sidle during the first season before departing, while Marg Helgenberger reprises her CSI: Crime Scene Investigation role as Catherine Willows beginning with season two.
Wallace Langham, Paul Guilfoyle and Eric Szmanda also reprise their roles as David Hodges, Jim Brass and Greg Sanders, in a guest capacity.
Originally branded as an epilogue limited series, the show was renewed for a second season in December 2021, without Fox, Petersen, or Rodriguez returning.
... Catherine would still be running the crime lab, ... [Brass] probably would retire, ... and DB probably is working in the private sector in Washington DC.
[54] On August 10, 2020, it was announced that the series was still in development, now titled CSI: Vegas, with the original star of CSI: Crime Scene Investigation, William Petersen, set to executive produce alongside Tracey, Bruckheimer, Littman, KirstieAnne Reed, Zuiker, Craig O'Neill, and Cynthia Chvatal.
[1] CBS Entertainment president Kelly Kahl confirmed that the second season will be longer than 13 episodes, although the network currently has "not done a final tally yet".
[6] On February 10, 2020, it was announced that two of the original stars of CSI: Crime Scene Investigation, Petersen and Jorja Fox, were in talks to potentially reprise their roles as Gil Grissom and Sara Sidle.
[61] Later that day, it was revealed that Wallace Langham would reprise his role as David Hodges, and Petersen and Fox were officially announced as being cast.
[62] In September 2021, Zuiker hinted that additional CSI: Crime Scene Investigation characters may make appearances in the series.
[63] On December 15, 2021, it was announced alongside the second season renewal that Petersen won't return as a cast member, though he would remain as executive producer.
[72] The series was originally planned to air on October 6, 2020, to mark 20 years since the day of the premiere of CSI: Crime Scene Investigation.