[2][P 2] It is headquartered in Boca Raton, Florida,[1] and operates a total of 320 collection centers in the United States,[P 3] and a further 19 more in other nations including China, Hungary, and Germany as of 2023[update].

[P 6] The company had previously partnered with the Red Cross to help provide relief after natural disasters including fires, hurricanes, and tornadoes that affected donation areas and staff.

[5] In January 2020, CSL Plasma was sued after misdiagnosing an Illinois man with HIV after a blood test and notifying the Food and Drug Administration before it was confirmed it was a false positive.

[6] In August 2023, CSL Plasma satisfied an agreement to end two Minnesota court cases from March 2019[7] and November 2019, moving to bar facilities from preventing potential donors from donating based on gender identity.

[8] In December 2023, another settlement was reached in an Illinois lawsuit that alleged CSL Plasma had violated the Americans with Disabilities Act and Illinois Human Rights Act after discriminating against disabled potential donors, leading CSL Plasma to adopt new policies for potential donors who are deaf or require a service animal.

[9][10] In January 2024, emergency medical support had to be provided to a donor in Maine after certain unspecified equipment was missing from the facility they were at, closing it until a replacement arrived.