[5] Substitute anchors include Butts (for weekday broadcasts), Anne-Marie Mediwake, Todd van der Heyden, Joy Malbon, Vassy Kapelos, John Vennavally-Rao, Heather Wright, Merella Fernandez and Jon Erlichman.

In 1992, its ratings jumped significantly after the CBC's unsuccessful relaunching of its newscast as Prime Time News.

This was because CTV National News only produced one edition for the entire network, which aired live at 11:00 pm EST.

[10] Larry Henderson, the former host of The National was CTV's international affairs analyst and weekend anchor for several years.

For a time in the late 1970s and again in the early 1990s, Keith Morrison acted as weekend and substitute anchor and was considered Robertson's likely successor[12] before a network shakeup resulted in his moving to NBC News.

Sandie Rinaldo served as weekend anchor from 1985 until her 2023 promotion to host the weeknight early edition, excluding a brief period from 1990 to 1991.

On August 15, 2022, it was announced by Bell Media and CTV that LaFlamme's contract was not being renewed by the network due to a "business decision" to take the newscast "in a different direction".

[15] In particular, CTV News head Michael Melling faced scrutiny when it was revealed that he had asked in internal memos for an explanation of who had permitted LaFlamme to make that decision, and had sparred with LaFlamme over the costs involved in covering both the Russian invasion of Ukraine and the Platinum Jubilee of Elizabeth II.

[16] CTV denied the allegations that LaFlamme's age or hair colour had entered into the decision,[17] and announced a workplace review.