158213124ENSG00000180432ENSMUSG00000050445Q9UNU6O88962NM_004391NM_010012NP_004382NP_034142CYP8B1 (cytochrome P450, family 8, subfamily B, polypeptide 1) also known as sterol 12-alpha-hydroxylase is a protein which in humans is encoded by the CYP8B1 gene.

The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.

[6] The elephant, manatee and naked mole rat have inactive copies of this gene and lack cholic acid in their bile.

[7] Relaxed selection resulting from changes in diet to consume less lipids might have contributed to the loss of this gene in several species.

[8] This article incorporates text from the United States National Library of Medicine, which is in the public domain.