Cañón del Usumacinta is a protected natural area in southern Mexico.

The Cañón del Usumacinta Flora and Fauna Protection Area covers 461.28 km2.

[1] The Usumacinta River forms the western boundary of the protected area.

The Guatemalan border forms its southern boundary, where it adjoins Guatemala's Sierra del Lacandón National Park.

The Cañón del Usumacinta is in the Petén–Veracruz moist forests ecoregion, evergreen tropical rain forests that extend from Mexico's southern Gulf Coastal Plain across northern Guatemala and Belize to the Caribbean Sea.