[2] At a secluded island laboratory CPEC, Dr. Edwards and fellow researchers Camila and Bridgett studies Mr. Porter, carrier of a deadly flesh-eating virus.

While Josh performs oral sex on her, Penny begins spitting up large amounts of blood and her flesh starts melting.

Penny sees Bridgett trying to steal the dinghy and the two infected women fight to the death, dismembering each other in the process.

They discover that Porter infected their water by injecting his blood into the bottles with a syringe before killing the boat captain and escaping in the dinghy.

Cabin Fever: Patient Zero Original Motion Picture Soundtrack was released on July 22, 2014, under the record label Sumthing Else Music Works.

"[9] Scott Foundas of Variety described the film as "thoroughly lousy" and wrote: "Characters reliably behave with the utmost stupidity, entering a quarantine zone with no hazmat suit and venturing alone into the woods, as they navigate the obligatory genre gauntlet of zombified corpses and poor cell-phone reception.

"[10] Robert Abele of the Los Angeles Times called the film a "slack, dumb prequel", and wrote: "Director Kaare Andrews’ and screenwriter Jake Wade Wall's interminable set-up is hardly worth the uninspired rollout of the second half's carnage follies, which save the most debilitating anatomical shredding and pulverizing for two female characters, who square off ... for the benefit of misogynistic gore pervs everywhere.

"[11] Ben Kenisberg of The New York Times wrote: "Less methodical and witty than its predecessors, Patient Zero often turns its infected characters into mindless, lurching zombies.

"[12] Rob Staeger of The Village Voice was more positive in his review, writing that the film "delivers its share of anticipated gross-outs, which director Kaare Andrews presents with a sly, often lipless, grin", and praised the makeup effects.

[13] A fourth entry in the series, titled Cabin Fever: Outbreak, was planned to be filmed back-to-back with Patient Zero, but was scrapped.