It conntects the towns of Cadenazzo and Luino, crossing the Italy–Switzerland border.

The line was opened on 4 December 1882 by the Gotthardbahn.

On 1 May 1909 it became part of the Swiss Federal Railways.

The railway is served by the S30, operated by TiLo.

Media related to Cadenazzo–Luino railway line at Wikimedia Commons