The first Cadillac sedan to be offered with All wheel drive, it retained the Seville's high-performance Magnetic Ride Control suspension.

The STS for model year 2008 received minor exterior revisions, including a larger grille and chrome fender vents.

The standard powertrain was a direct-injected 3.6 L V6 mated to a six-speed automatic transmission, which in the STS produced 302 hp (225 kW) and 272 lb⋅ft (369 N⋅m) of torque.

[13] The Cadillac STS-V is a high-performance executive car of the V-Series introduced at the 2005 Detroit Auto Show, and was available for sale in late 2005.

Also different from the standard STS, the STS-V has a cooler for the rear differential oil located on the underside of the car behind the 3rd member.

[15] The STS-V's primary visual difference from the standard STS was a wire mesh grille and a 'power-dome' hood as well as six lug wheels normally seen only on larger SUVs, trucks and pickups.

In addition to the grille, the front differences include the bumper, the fog light and turning signal cluster, and the hood which is slightly domed to fit over the supercharger.

For the interior, the STS-V also has upgraded leather and suede trim contracted from the German company Dräxlmaier, whose prior credit includes the Maybach 57 and 62.

Interior color choices were Ebony and Gray, both of which are offered on the standard STS as well, and a two-tone Ebony/Tango Red scheme which was unique to the STS-V. Production numbers The model was discontinued in 2009.

[26] The enlarged third generation rear-wheel drive CTS sedan introduced in 2013 as a 2014 model, similar in size and price to the STS, effectively succeeded it.