Caecidotea nickajackensis is a species of isopod crustacean in the family Asellidae.

[2] In 2013 Caecidotea nickajackensis was discovered within Horseskull Cave and Raccoon Mountain Caverns.

[2] Caecidotea nickajackensis was first described by Alpheus Spring Packard, in an 1881 publication by Edward Drinker Cope and himself, titled The Fauna of Nickajack Cave.

[2][4] A second species, C. richardsonae, was described from the same cave by William Perry Hay in 1901, and was thought to be a junior synonym of C. nickajackensis for a long time.

[2] It was now recognised as a separate species distributed from Alabama to Virginia.