Cain's Hundred is an American crime drama series that aired on NBC from 1961 to 1962.

The series was produced by Vanadas Productions, Inc. in association with MGM Television.

After becoming engaged to be married, Cain decides to leave his life of crime.

His departure from the underworld, however, prompts a mob boss to put out a "hit" on him, but the gunman misses Cain and mistakenly kills his fiancée Stella (portrayed by actress Carol Rossen).

Seeking revenge, Cain then teams up with the Federal Bureau of Investigation to find and bring 100 mobsters to justice.