Cain Ginyilitshe Ndabazekhaya Mathema (born 25 January 1947) is a Zimbabwean politician and writer.

[8] In late February 2008, he was present at rally supporting ZANU-PF candidate Sikhanyiso Ndlovu's bid for the Pelandaba-Mpopoma constituency seat.

[9] On 6 November 2018, he promised to crush anti-government demonstrations which he alleges were being planned by Nelson Chamisa[citation needed].

Cain Mathema is a published Ndebele and English poet, playwright, short story writer and cartoonist.

In December 2016, Cain who was then Matebeleland North Provincial Governor, married 23-year-old Bathabetsoe Nare who was 47 years his junior.