Its main hub is Cabo San Lucas Airport and has focus city operations in La Paz and Loreto.

Aéreo Calafia became the first regional airline to offer tours for observing grey whales, at the Sea of Cortez during the winter months.

They also successfully introduced tours to destinations such as San Ignacio Lagoon, Copper Canyon, Loreto, Cabo Pulmo National Park, and La Paz.

It also added new cities to its network, including Chihuahua, Guadalajara, Tijuana, Mexicali, León, and Monterrey, connecting the Gulf of Mexico to the Pacific Ocean.

[7] In August 2023, Calafia Airlines suspended operations temporarily due to pending procedures with the Mexican Civil Aviation Federal Agency, leaving passengers stranded.