Caldecote (pronounced "Kal-de-COAT) is a hamlet in the civil parish of Moulsoe in the City of Milton Keynes, Buckinghamshire, England, situated roughly 1 mile (1.6 km) south of Newport Pagnell, and roughly 3 miles (4.8 km) north-east of Central Milton Keynes.

The original Northampton to London road (modern B526) runs nearby.

The route was diverted in 1728 along a new road on the higher ground east of the village, causing the latter to decline.

It is mostly farmland and designated as urban open space since it is substantially within the flood plain of the River Ouzel (or Lovat).

There is also another ancient village (and now a modern development and balancing lake) in Milton Keynes with a very similar name of Caldecotte.