In 2020, CHSU established the College of Osteopathic Medicine to train primary care physicians for the Central Valley, an area that previously lacked a medical school.

Established to address the need for primary care physicians in the Central Valley region, it confers a Doctor of Osteopathic Medicine (DO) degree.

In December 2018, the college received approval to begin recruiting students, with the inaugural class commencing studies in the Fall of 2020[9] and graduating in May 2024.

The curriculum also incorporates Spanish language training to prepare students to serve the diverse patient populations in the region.

[11] The institution utilizes technology for virtual 3D anatomical training, in lieu of traditional cadaver labs for anatomy instruction.

Clerkships for third and fourth-year students primarily take place in the Clovis/Fresno area, with additional opportunities in surrounding regions and other parts of California through prior arrangements.

[17] The campus at 2500 Alluvial Ave consists of a 90,000 sq-foot three-story building, newly constructed in 2020, housing the College of Osteopathic Medicine.