SR 94 is an east–west freeway that begins at the eastern end of the one-way couplet of F and G streets in southeast San Diego.

Following this, the route goes through the neighborhoods of Sherman Heights, Grant Hill, Stockton, and Mount Hope, where there is an interchange with SR 15.

At this point, SR 94 leaves both cities and enters unincorporated Spring Valley and Casa de Oro.

[20] In 1931, the County Board of Supervisors agreed to submit the Campo road for consideration as a secondary state highway.

[24] The Chamber also asked for the war department to declare the road a military highway to receive federal assistance for its improvement.

[33] The local Board of Education also gave their approval, which was required because the freeway would be built on land that was for a proposed school.

[34] But the next month, State Senator Fred Kraft criticized the proposal because he believed that it would be too expensive and would not reduce congestion in the long term.

[36] Later that year, a toll road that would have tunneled under the Laguna Mountains and bypassed Route 94 was proposed by the county Board of Supervisors.

[42] The San Diego City Council requested that an overpass be constructed at 22nd Street to provide improved access;[43] an underpass for the road was eventually built.

[3] The freeway from Wabash Boulevard and 56th was completed on March 18, 1957; metal-weakened plane joints were used for the construction, which the California Division of Highways considered "experimental" at the time.

East of College Avenue, some unwanted cracks developed in the roadway during the joint pouring process, and were repaired with epoxy.

[44] At one point in 1958, SR 94 was considered as a possible extension of US 90, a route proposed to run along the southern border of the United States to Florida, by the South Bay Highway Association.

[52] The next year, a plan to reroute and widen portions of SR 94 from the Sweetwater River to I-8 was underway, with a Caltrans proposal to remove the "Frenchy's" or "Three Springs" curve.

[53] In March 1968, the San Diego Highway Development Association considered the construction of the freeway from SR 125 to Jamacha Junction a priority.

[67] In 1995, a U.S. Border Patrol checkpoint was opened near Dulzura, to combat human and drug trafficking that used SR 94, as well as fatal traffic accidents resulting from such smuggling.

[69] In July 1998, the Back Country Coalition sued Caltrans concerning the short length of the environmental impact report as well as not soliciting comments from the public; opponents pushed for a ban of all trucks on the highway.

[73] In late 2006, the Jamul Indian tribe prepared to construct a casino, but many expressed concerns about the amount of traffic that would now travel on SR 94.

[75] At the end of the year, the tribe had started construction on the driveway to the casino, while Caltrans stated that it lacked the information needed to determine if the proposed traffic signal should be approved.

[81] Except where prefixed with a letter, postmiles were measured on the road as it was in 1964, based on the alignment that existed at the time, and do not necessarily reflect current mileage.