The series stars Mayim Bialik as Kat, and includes Cheyenne Jackson, Kyla Pratt, Julian Gant, and Swoosie Kurtz.

Instead, Kat starts earning income by tutoring math students and renting her apartment, forcing her to move back in with her mother.

Kat's tenants (Kelly and Shrub) leave the bathtub running and the excess water collapses the ceiling of the café below.

Kat tries to find another sperm bank but is denied service due to stalking a donor at the first clinic she tried.

Kat is initially excited but when she learns that Max dropped out of college, she declines to accept his sperm.

Phil takes an interest in a drag queen he meets at the Middle-C. Kat throws a murder mystery-themed "friendsgiving" and insists her friends/guests dress in character and participate.

Sheila volunteers to do it, and does so just after Lurlene has learned Phil is not returning to Kentucky; he and Jalen plan to marry in Tahiti and run a bakery there.

[1][58] The series was to be executive produced by Mayim Bialik and Darlene Hunt through Sad Clown Productions, Jim Parsons (Bialik's former co-star on The Big Bang Theory) and Todd Spiewak through That's Wonderful Productions, and Angie Stephenson and the original series creator and star Miranda Hart through BBC Studios.

[64][65] On June 9, 2022, Jim Patterson and Maria Ferrari were announced as the new showrunners for the third season, replacing Neubauer.

Hunt is not the only Louisville-area native involved in the series' production; a co-executive producer and writer, Amy Hubbs, is from Elizabethtown, Kentucky.

Hunt chose not to reveal Kat's allegiance before the series premiere, but confirmed that the chosen university sent several items to be used in decorating the character's home.

[2] According to Yates, the series is "chock full of Louisville references", with the first three episodes alone making multiple references to Louisville cultural touchstones and locations such as the UK–U of L rivalry, bourbon, the Brown Hotel, Churchill Downs, and Muhammad Ali.

Hunt further added, "It does feel really special to be able to make so many shoutouts to people, places and things around Louisville and to be able to honor them in the show.

"[2] Bialik confirmed that the show is filmed on a closed set without a studio audience due to COVID-19; a laugh track is added during post-production.

[2] On October 24, 2022, Leslie Jordan was killed in a car crash,[74] and it was announced that production on the series had paused indefinitely in the wake of his death.

[78] Call Me Kat was filmed at Warner Bros. Studios in Burbank, California, but it is set in Louisville, Kentucky.

The website's critical consensus reads, "More gimmick than sitcom, Call Me Kat buries a charming Mayim Bialik in a sandbox of toothless jokes and shallow characterizations.