Callum made his debut for the West Coast Eagles in Round 10, 2000 against Hawthorn.
However, as the Eagles' midfield was flooded with new talent, he struggled to make an impact and be selected for games on a consistent basis.
He showed glimpses of brilliance as he helped the team to win the 2005 Pre-Season premiership.
However, his form faded away fast in the main season struggled to have much impact at AFL level, playing most of his 2006 for the Northern Bullants seniors.
In 2008, Chambers played an excellent season, and finished second for the Sandover Medal, two votes behind Peel's Hayden Ballantyne.