Headquartered in Lisbon with centers across five continents, the mission of the Instituto Camões is the promotion of Portugal's language, culture, values, charity, and economy.

The Instituto Camões head office is headquartered at Seixas Palace, a 19th-century mansion on Marquis of Pombal Square, in Lisbon, Portugal.

New centres are presently being established in Paris and in the headquarters of the African Union in Addis Ababa and of the Economic Community of West African States in Abuja and in 2005, the towns of Canchungo, Ongoré, Mansôa, Bafatá, Gabú, Buba, Catió, Bolama, Bubaque, and Quinhamel in Guinea-Bissau to spread the fluency of Portuguese as the official language in the country.

Angola: Benguela, Lubango, and Luanda Argentina: Buenos Aires Austria: Vienna Belgium: Antwerp Brazil: São Paulo and Brasília Canada: Toronto Cabo Verde: Praia China: Beijing, Shanghai and Macao (as Instituto Português do Oriente) Croatia: Zagreb Czech Republic: Prague Estonia: Tallinn Ethiopia: Addis Ababa France: Lille, Lyon, and Poitiers Germany: Hamburg Guinea-Bissau: Bissau Hungary: Budapest India: Goa (as Instituto Português do Oriente) Italy: Florence and Milan Mexico: Mexico City Moldova: Chișinău Morocco: Casablanca, Rabat Mozambique: Beira, Lichinga, Maputo, Nampula, Quelimane, and Xai-Xai Namibia: Windhoek Poland: Lublin Romania: Bucharest, Cluj-Napoca, and Constanta São Tomé and Príncipe: São Tomé Senegal: Dakar Serbia: Belgrade South Africa: Johannesburg South Korea: Pusan (as Instituto Português do Oriente) Spain: Barcelona, Madrid, Cáceres, and Vigo Sweden: Stockholm Timor-Leste: Dili (as Instituto Português do Oriente) Tunisia: Tunis United Kingdom: London, Edinburgh, Leeds, Newcastle and Oxford United States: Boston, Newark, and San Diego Venezuela: Caracas The Institute's Portuguese cultural centres (Centros culturais portugueses) are centres whose aim is the promotion of cultural relations between Portugal and other countries, including those with which Portugal has strong historical and cultural ties, and where Portuguese is already widely spoken.

Angola (Luanda) Brazil (Brasília) Cape Verde (Praia, Mindelo) China (Beijing) France (Paris) Germany (Berlin) Guinea-Bissau (Bissau) India (New Delhi) Japan (Tokyo) Luxembourg (Luxembourg) Morocco (Rabat) Mozambique (Maputo, Beira) São Tomé and Príncipe (São Tomé, Santo António) Spain (Vigo) Thailand (Bangkok) Timor-Leste (Dili)