Cuffe was born in West London to an English mother and an American father of Irish and Italian descent.
At 18 he moved to Ireland and went on to graduate with a Bachelor of Arts in Acting from The Lir Academy at Trinity College Dublin in 2014.
[4] Cuffe began his professional career in London, appearing in the Park Theatre production of The Vertical Hour[5] as Dennis Dutton and the Donmar Warehouse production of City of Angels as Peter Kingsley.
[6][7] Cuffe appeared in the 2016 biographical film Florence Foster Jenkins and had a recurring role in the 2017 ITV drama series The Halcyon.
[12] In 2022 Cuffe portrayed Patrick in Dolly Alderton's Everything I Know About Love for the BBC and Working Title as well as filming the 2024 adventure TV series Nautilus.