Originally called "Duke Indoor Stadium", it was renamed for Cameron on January 22, 1972; that day the Blue Devils beat archrival North Carolina 76–74.

Renovations in 1987–1988 removed the standing room areas, added an electronic scoreboard and display over center court, wood paneling, brass railings and student seats, bringing capacity to 9,314, though now[when?]

Prior to the 2002–2003 basketball season, air conditioning units were installed in Cameron for the first time as a response to health and odor concerns for players and fans alike.

[6] Before the 2009–10 season, additional changes were made, including installing LED ribbon boards to the front of the press table and painting the upper seats Duke blue.

The students and fans are known as "Cameron Crazies" for their support of the team and loud cheering that has been recorded as high as 121.3 dB, which is louder than a power saw at 3 feet or a jackhammer.

[8] For access to major games, including those against the University of North Carolina, students reside in tents for months in an area outside of Cameron known as "Krzyzewskiville", named after head coach Mike Krzyzewski.

On November 26, 2019, the Duke men's team non-conference home winning streak of 150 games ended with an overtime loss to Stephen F. Austin, 85–83.