He quickly became a regular at Ninian Park and after scoring 20 goals in the 2005–06 season he was signed by Birmingham City for a fee of £3 million.

He spent five years at St Andrew's where he experienced two promotions and two relegations and also helped the side win the 2011 Football League Cup.

After not figuring in new manager Mark Hughes' plans Jerome joined Crystal Palace on loan for the 2013–14 season.

Jerome joined Norwich City in August 2014, and after 138 appearances in three and a half years, he signed for Derby County in January 2018.

[4] As a youth, Jerome played for Stile Common, alongside Anthony Griffith, Fraizer Campbell, and Reuben Noble-Lazarus, who all went on to enjoy careers as professional players.

[7] Described by the BBC as "one of Cardiff's rising stars", Jerome made his debut in a 0–0 draw with Leeds United on 2 October 2004, as a substitute for Andy Campbell.

The move not only benefitted Jerome but also helped Cardiff as they used the transfer money to sign Michael Chopra, Stephen McPhail and Glenn Loovens.

[citation needed] Jerome signed for Birmingham City on 31 May 2006, for a transfer fee reported as an initial £3 million, potentially rising to £4m.

"[15] Jerome hit a purple patch as the Blues notched up a club-record fifteen consecutive games unbeaten in the Premier League, scoring crucial goals against Stoke City, Manchester United and two versus Blackburn Rovers.

[22] On 31 August 2011, the last day of the transfer window, Jerome signed a four-year contract with Premier League club Stoke City for an undisclosed fee, believed by Sky Sports to be £4 million.

[23] He scored on his Stoke City debut in the UEFA Europa League against Dynamo Kyiv to earn his side a 1–1 draw away from home.

[30] In a rare appearance, against Newcastle United on 28 November 2012 coming on as a substitute, he provided an assist for Jonathan Walters and then scored the winning goal.

[31][32] On 29 December, Jerome "lashed into the top corner from 30 yards" to score Stoke's third goal in a 3–3 draw with Southampton in the final minute of the match.

[41] After a poor start to the season Ian Holloway left Palace by mutual consent and Tony Pulis was appointed manager on 23 November.

Despite Jerome criticising Pulis towards the end of his time at Stoke, he started and scored against his former club Cardiff City on 7 December.

Milton Keynes Dons manager Russell Martin moved to bring his former teammate to the club on a free transfer of an undisclosed length.

[65] In June 2021, Championship club Luton Town confirmed Jerome would join them when his contract with MK Dons expired.

[66] Having found travelling from his home in the north-west of England increasingly problematic, Jerome left Luton Town on 27 January 2023 after his contract was cancelled by mutual consent.