[9][10] After working freelance with Good Morning America for several years, Mathison signed with GMA in January 2009 as a regular correspondent.

Mathison continued to work as a host and correspondent for GMA, the Emmy-nominated series Ultimate Proposal,[11] and the renovation reality show Game of Homes.

He has appeared on Castle, Desperate Housewives, Hot in Cleveland, Drop Dead Diva, the EXes, and numerous independent and television films.

Mathison appeared in 8 movies based on the Murder She Baked novels starring opposite Alison Sweeney.

[16] On July 26, 2018, Mathison was named the new co-host of Home & Family, alongside Debbie Matenopoulos; he assumed his position in September with the launch of the seventh season.

[17] In April 2021, Deadline Hollywood announced Mathison had joined the cast of General Hospital as "Drew Cain".

[19] In November 2023, it was announced that Mathison had signed a multi-picture deal with Great American Family over the next several years, moving on from the Murder, She Baked movie series and Hallmark.