[1] After leaving the University of Cambridge, Wedgwood returned to Bedford College as an assistant lecturer in the Department of Social Studies.
[1][3] After Arthur Bernard Deacon's death in 1927, she was invited to move to the University of Sydney to replace him as lecturer in anthropology.
[4] In 1930, she held a temporary lectureship in the Department of African Life and Languages at the University of Cape Town.
[1][3] In 1932, Wedgwood was awarded a fellowship by the Australian Research Council to conduct fieldwork on Manam Island off the north coast of Papua New Guinea on the border of modern Madang and East Sepik provinces.
[2] During World War II, Wedgwood was involved in formulating policy on education and administration in Papua New Guinea.
[1] Having renounced her pacifism, she volunteered for the Australian Army Medical Women's Service and was commissioned as a temporary lieutenant colonel in January 1944.
[3] She continued in this role until her death on 17 May 1955 of lung cancer at Royal North Shore Hospital, Sydney.