His sisters were Maria Flaminia Pamphili (1619 - 1682), married on 12 October 1640 to Andrea Giustiniani, Marquess and 1st Prince of Bassano on 21 November 1644 (?

[4] Camillo was created Cardinal Deacon in the consistory of 14 November 1644 with the titulus Santa Maria in Domnica; and Cardinal-nephew a month later.

[1] Though he was described as a happy young man, pleasant to friends and staff, contemporary records of his cardinalate suggest he lost interest in his new-found piety fairly quickly,[3] leading a lazy life, sometimes not rising from bed until 7:00 pm.

The role of cardinal-nephew had become by the second half of the sixteenth century a significant position in the administration of the Papal States, but Innocent X distributed much of the responsibilities.

Military tasks were delegated to his two brothers-in-law, Niccolò Ludovisi and Andrea Giustiniani, husband of his older sister Maria Flaminia.

According to Theodoro Ameyden, by 1646 the pope was again thinking of his nephew, the only male heir of the Roman Pamphili, marrying and at this stage there reappeared on the horizon the possibility of a marriage alliance with the Barberini.

[2] Camillo developed a particular interest in Olimpia Aldobrandini, a young noblewoman who had been in attendance at the Palazzo Pamphili the day after his uncle's coronation.

The two families were already close; Aldobrandini's maternal uncle, Niccolò Ludovisi, had married Camillo's sister, Costanza.