Created by Tiago Santiago and directed by Alexandre Avancini, it was replaced by a spin-off called Os Mutantes: Caminhos do Coração, airing since June 3, 2008.

The plot develops around Maria Luz who is accused of killing Dr. Socrates Mayer, owner of one of the largest private clinics in the country, Progênese.

Dr. Júlia, an affiliated physician of Progênese created genetically modified human beings, mutants with superpowers.

Júlia has always maintained a secret laboratory on the fictional island of Arraial, where she performs the experiments that originated the mutants.

Ari is widowed and has three mutant children: Toni, who can deviate from bullets and has over human strength, Rodrigo, who has hypnotic powers, and Danilo, who has super agility and marries Lucinha to hide his homosexuality from his father.

Platão is married to Irma and has two daughters: Regina and Cléo, who are discovered to have the powers of survival and astral projection.

In the following season, Os Mutantes: Caminhos do Coração, Júlia drank some of the youth serum that she produced and adopted the pseudonym of Juli Di Trevi.

On February 6, 2008, Caminhos do Coração became the first Rede Record telenovela to achieve the first place on the São Paulo TV rank.