The prisoners brought to Camp Crame included former President Sergio Osmeña's son Sergio Osmeña III, Senators Soc Rodrigo and Ramon Mitra, businessman Eugenio Lopez Jr., teacher Etta Rosales, lawyer Haydee Yorac,[9] and a plethora of writers and broadcasters including Amando Doronila of the Daily Mirror, Luis Mauricio of the Philippine Graphic, Teodoro Locsin Sr. of the Philippines Free Press, Rolando Fadul of Taliba, Robert Ordoñez of the Philippine Herald, Rosalinda Galang of the Manila Times; Ernesto Granada of the Manila Chronicle, Maximo Soliven of the Manila Times, and Luis Beltran and Ruben Cusipag of the Evening News.

[11] Others who were detained in Camp Crame at different times during the Marcos dictatorship were writers Luis R. Mauricio and Ninotchka Rosca, Obet Verzola, Dolores Stephens Feria, Boni Ilagan, and Pete Lacaba, among others.

[12][15] Camp Crame was also the site of the Command for the Administration of Detainees (CAD), headed by PC Chief Fidel V. Ramos, which was the agency in charge of giving orders for the arrest and detention of the Marcos regime's political prisoners.

Hoping to take advantage of the disarray, the Reform the Armed Forces Movement (RAM) under then-Defense Secretary Juan Ponce Enrile attempted to stage a coup, and took over Camp Aguinaldo.

[19] Marcos ordered the Philippine Air Force’s 15th Strike Wing, commanded by Colonel Antonio Sotelo, to neutralize the helicopters in Camp Crame.

[citation needed] Camp Crame host the PNP Custodial Center which serves as a detainment facility for high profile suspects.

The ongoing trial for the Maguindanao Massacre is also held in a courtroom inside the camp, where primary suspect Datu Unsay mayor Andal Ampatuan Jr. is being detained.

[23] Dismissed Bamban mayor Alice Guo, who is facing charges related to her alleged links with the Philippine Offshore Gaming Operator (POGO), was also detained here in September 2024.