Its eastern terminus is at an interchange with Interstate 85 (I-85) west of the Hartsfield–Jackson Atlanta International Airport.

SR 6 starts at the Alabama state line, southwest of Cedartown, and northwest of Esom Hill in Polk County, and initially heads east to Cedartown, concurrent with US 278 from its western terminus.

Bypassing Dallas to the south, SR 6 continues traveling to the southeast and travels through the southwestern corner of Cobb County, through Powder Springs, to Austell in Douglas County.

In Lithia Springs, the highway approaches the intersection with US 78/SR 5/SR 8, where US 278 turns left and joins a concurrency with US 78 as far east as Druid Hills, while SR 6 continues southeast where it has an intersection with Maxham Drive, a local boulevard spanning from the Westfork Shopping Center through SR 5, and later crosses over I-20, where it has a partial cloverleaf and half-diamond interchange.

Curving to the east, the highway crosses I-285 and reaches its eastern terminus at the western edge of Hartsfield–Jackson Atlanta International Airport in College Park.

[3] By the end of September 1921, it was extended westward to the Alabama state line.

[4][5] About 20 years later, between the beginning of 1945 and November 1946, the entire segment from Alabama to Austell was hard surfaced.

At this time, Camp Creek Parkway was established from Welcome All Road west-southwest of College Park to US 29/SR 14 in the city.

Camp Creek Parkway was extended north-northwest to connect with the eastern terminus of SR 6.

[28][29] In 1987, SR 6 was extended on the entire length of Camp Creek Parkway, to its eastern terminus.

[32] Recently, at the intersection of SR 6 and I-285 in East Point, there has been a renaissance for southern Fulton County: the opening of the Camp Creek MarketPlace.

[33] As of March 2009, the portion of the highway in Fulton County is no longer signed as SR 6.

begins along Buchanan Street as SR 120 turns right onto the intersection with US 278/SR 6 (Jimmy Campbell Parkway).

Buchanan Street ends at West Memorial Drive, and SR 6 Bus.

encounters a paved trail that turns along the south side of the road, then both travel on bridges over Weaver Creek and then travel under a railroad bridge, before making a curve back towards the east-northeast as it gets closer to downtown Dallas.

The highways travel south-southeast down a hill along the eastern edge of downtown Dallas, but then begins to elevate in the vicinity of the local post office.

at Nathan Dean Boulevard, and later the road curves from south-southeast to southeast at Hardee Street, formerly SR 6 Spur.

At New Canaan Baptist Church and Cemetery, the road descends along another hill, but climbs back up before the intersection with Cobbler Cove Drive.

starts to curve to the southeast and approaches an intersection with SR 120/SR 360 (Charles Hardy Parkway).

Shortly after this, the business curves to the southeast and then to the south-southwest to end at US 278/SR 6 at the intersection with the northern terminus of Highland Falls Boulevard.

In 1983, a western bypass of the cities, designated as SR 726, was proposed from an unnumbered road south-southwest of Powder Springs to US 78/SR 5/SR 8 southwest of Austell.

It continues to the northwest until it reaches its eastern terminus, an intersection with Powder Springs Road.

Here, the roadway continues as Westside Road, which provides access to Luke Garrett Middle School.