In November 2003, the site was reconstructed by US Army soldiers of C Battery, 3rd Battalion, 321st Field Artillery Regiment from Fort Bragg, North Carolina.

In July 2010, the 1st Brigade Combat Team, 4th Infantry Division (United States), took command of Camp Nathan Smith.

Its location in the heart of Kandahar City allowed ISAF forces to quickly respond to enemy attacks during the early years of the Afghan war.

There was a small post exchange, a local bazaar, an aid station, a gym, a water reservoir and two dining facilities at Camp Nathan Smith.

On July 31, 2013, Camp Nathan Smith was transferred to the Afghan Uniform Police by the US Army (1 Armored, 1st Brigade Combat Team).