In 1990, Scott played a lead role in the ground-breaking film Longtime Companion, which chronicles the early years of the AIDS/HIV epidemic and its impact upon a group of American friends.

[9] He also appeared in the 1992 Cameron Crowe movie Singles alongside Bridget Fonda and Kyra Sedgwick,[10] and in 1996, he teamed up with Stanley Tucci to direct the film Big Night.

[14] In 2005–2006, Scott served as the reader for the audiobook versions of Stephen King's bestsellers The Shining[15] and Cell, and for Ernest Hemingway's For Whom the Bell Tolls.

[16] In 2007, Scott lent his voice for the narration of a Chevron Corporation television ad,[17] as well as the Iraq War documentary film, No End in Sight.

In 2017, he collaborated with Dutch DJ and producer Ferry Corsten on Blueprint, an album combining Trance music and science fiction, in which he can be heard as the story's narrator.

[21] In 2019 Scott portrayed the lead role of Ebenezer Scrooge in a Broadway adaptation of Charles Dickens's A Christmas Carol written by Jack Thorne and directed by Matthew Warchus.

Scott met his current wife Kathleen McElfresh, in 2007 when the two were working on separate plays at the Huntington Theater, in Boston.