In 1456, under Pope Callixtus III, Ludovico Cardinal Trevisani paved the area as part of a large project to improve rione Parione.

This urban development brought wealth to the area: A flourishing horse market took place twice a week (Monday and Saturday) and many inns, hotels and shops came to be situated in Campo de' Fiori.

It belonged to Vannozza dei Cattanei, the most famous lover of Alexander VI Borgia, whose family seal is still on display on the house facade.

Here, on 17 February 1600, the philosopher Giordano Bruno was burnt alive for heresy, and all of his works were placed on the Index of Forbidden Books by the Holy Office.

In 1889, Ettore Ferrari dedicated a monument to him on the exact spot of his death: He stands defiantly facing the Vatican and was regarded in the first days of a reunited Italy as a martyr to freedom of thought.

[2] A plaque commemorating this incident was affixed to the marketplace street in Campo de' Fiori in 2011 (the idea of memorializing this event was inspired by the monument to Giordano Bruno).