Campodimele is a town and comune in the province of Latina, in the Lazio region of central Italy.

Campus Mellis rose probably over the roof Apiola, a very ancient Latin city, destroyed by Tarquinius Priscus, fifth king of Rome (579 BC); the ruins of Apiola are visible 6 kilometres (4 mi) away from the present-day historic center of Campodimele.

In 1087, Pope Victor III had a list of the abbey's property sculpted onto the bronze door of the Basilica of Montecassino.

Alberto Moravia, who had been deported here, took inspiration from the happenings of the time for his novel La Ciociara.

Campodimele is known for the longevity of its residents, with the town's population now expected to live to an average age of 95.