Established in 1987 amidst the growing HIV/AIDS crisis and an inadequate governmental response, CAS initially began as a grassroots movement and later formalized into a coalition, incorporating in 1988.

At that time, the Canadian government's response to the epidemic was largely inadequate, resulting in insufficient support and resources to address the challenges posed by HIV/AIDS.

These conferences played a crucial role in mobilizing efforts to combat the epidemic on a broader scale, leading to the establishment of CAS as a national umbrella organization.

Led by Michael Phair, its first board chair from Edmonton, CAS relocated to Ottawa and obtained charity status, providing greater access to government channels and a more stable funding base.

This emphasis on accountability to local organizations was imperative for CAS to uphold its credibility and effectiveness as a national advocacy entity.

Following the establishment of the First Annual Forum for PHAs in 1992, CAS has addressed a broad spectrum of issues relevant to PHA, including treatment and research, income security, housing and hospice care, and health promotion strategies.

Political momentum increased with the appointment of Perrin Beatty as Minister of Health in 1989, who committed to developing the NAS during the 5th International Conference on AIDS in Montreal.

CAS established itself as a credible organization on Parliament Hill, gaining direct access to Minister Beatty and influencing policy discussions.

[20] The Canadian AIDS Society (CAS) is overseen by a board of directors, which includes two representatives from each region of Canada, one of whom is required to be HIV-positive.

This shift, alongside broader underfunding issues for HIV/AIDS service organizations in Canada, has provoked strong criticism from various stakeholders, including CAS's national partner, the HIV Legal Network.

[40] Approved by Health Canada on November 3, 2020, the first HIV self-testing home kits serve as a tool to reduce the number of undetected infections.