The works in it were compiled during a time span of around 40 years, from the mid-1470s until the beginning of the 16th century, approximately coinciding with the reign of the Catholic Monarchs.
The manuscript was written by 9 different people and, in all, received 11 successive additions: By the end of the 19th century the manuscript was found in the Royal Library of the Royal Palace of Madrid by composer and musicologist Francisco Asenjo Barbieri, who transcribed and published it in 1890 with the title "Cancionero musical de los siglos XV y XVI" (Musical songbook of the 15th and 16th centuries).
The themes found in the songs are the most varied: romantic, religious, festive, chivalrous, satirical, pastoral, burlesque, political, historical, etc.
accompanied by music of all styles: from popular folk songs to elaborate compositions.
Below is a list of the composers present in the manuscript, with the number of works in parentheses: Three different indexing systems are used in the table below: