[7][8] Accola had guest appearances in a number of television series such as How I Met Your Mother, Supernatural, and Drop Dead Diva.

In July 2009, she starred in the horror film Deadgirl which centers on two high-school boys who discover an immortal woman in an abandoned asylum.

In June 2012, she joined the second season of the web series Dating Rules From My Future Self, as Chloe Cunningham, a 26-year-old woman who believes love does not exist.

[11][12] The series centers on a girl receiving romance advice from herself ten years in the future by text message.

[16] Along with her The Vampire Diaries co-stars Michael Trevino and Ian Somerhalder, Accola supports the It Gets Better Project, an organization that focuses to prevent suicide among LGBT youth.

[17] Accola started dating musician Joe King of The Fray after they met at a Super Bowl event in February 2012.