She won numerous awards and accolades as a college basketball player, drawing comparisons to the NBA's Tim Duncan.

[6][7] Source[8] Dupree was selected 6th overall in the 2006 WNBA draft by the Chicago Sky, an expansion team that year.

The Mercury would make it to the playoffs in an attempt to defend their title but were swept in the second round by the Minnesota Lynx who won the championship that year.

Dupree played all 22 games and averaged 12.5 ppg, but the Fever finished as the second worst team in the league with a 6–16 record.

[15] Dupree played professional basketball in Poland, for the TS Wisła Can-Pack Kraków club, during the 2007–08[16] and 2008–09 WNBA off-seasons.

In 2009, Dupree was named to the "Rest of the World" (non-European) squad for the EuroLeague Women All Star Game.

[18] Dupree played two consecutive off-seasons for Good Angels Košice in Slovakia from 2009 to 2011, winning a national championship with the team.

[19][20] From 2011 to 2015, Dupree played four off-seasons in Russia for WBC Spartak Moscow Region, Dynamo Kursk and Nadezhda Orenburg.

[22] In September 2018, Dupree signed with Sopron Basket of the Hungarian league for the 2018-19 off-season, she would return to the team for the following year.

Dupree averaged 7.6 points per game, helping the team to a 7–0 record, and a gold medal at the event.

[26] Dupree was invited to the USA Basketball Women's National Team training camp in the fall of 2009.

Dupree was selected to be a member of the National team representing the US at the World Championships held in September and October 2010.

Several players shared scoring honors, with Swin Cash, Angel McCoughtry, Maya Moore, Diana Taurasi, Lindsay Whalen, and Sylvia Fowles all ending as high scorer in the first few games.