Formerly the lead vocalist of the band Black and Blue, Lo launched her solo career in 1998 and is best known for the singles, "Trash" (垃圾) and "Please Break Up" (好心分手).

Her first release under Sony was the EP Don't Have to be...Too Perfect (不需要...完美得可怕) which contained the breakthrough radio-hit "Trash" (垃圾), considered one of her signature songs.

A substantially more commercial direction was signalled by the release of 2002's Appreciating the Taste of Life (賞味人間), which gave Lo her first-ever smash hit, "Please Break Up" (好心分手).

The song topped the charts and won her year-end awards at all four of Hong Kong's major radio and TV stations, making it a career highlight for Lo.

[4] In 2014, Lo signed onto the newly founded label, WhatsUp Music Limited and collaborated with the band Fabel on the single "Self-Love" (自戀自在).

"Self-Love" topped two of the four major Hong Kong singles charts and received a nomination for "Best Vocal Collaboration" at the 2014 CASH Golden Sail Music Awards.

In November 2018, Lo contributed vocals to the alt-rock single, "Sunset Party" (日落派對), as part of a collaborative project between composer Vicky Fung and lyricist Chow Yiu Fai.