Canine degenerative myelopathy
Onset is typically after the age of 7 years and it is seen most frequently in the German shepherd dog, Pembroke Welsh corgi, and boxer dog, though the disorder is strongly associated with a gene mutation in SOD1 that has been found in 43 breeds as of 2008, including the wire fox terrier, Chesapeake Bay retriever, Rhodesian ridgeback, and Cardigan Welsh corgi.
The Orthopedic Foundation for Animals has a DNA saliva test to screen for the mutated gene that has been seen in dogs with degenerative myelopathy.
It must be interpreted with caution by a veterinary clinician in combination with the animal's clinical signs and other lab test results.
As the disease progresses, the animal may display symptoms such as incontinence and has considerable difficulties with both balance and walking.
[1][4] If allowed to progress, the animal will show front limb involvement and extensive muscle atrophy and paralysis.
Eventually cranial nerve or respiratory muscle involvement necessitates euthanasia or long term palliative care.
Recent research has shown that a mutation in the SOD1 gene is a risk factor for developing degenerative myelopathy in several breeds.
[2] Mutations in SOD1 are also associated with familial amyotrophic lateral sclerosis (Lou Gehrig's disease) in people.
[9] Use of a belly sling or hand-held harness allows the handler the ability to support the dog's hind legs for exercising or going up and down stairs.
