It spans the Caloosahatchee River connecting McGregor and Cape Coral.

The original span opened for traffic on March 14, 1964, with one lane in each direction.

In conjunction with the new eastbound span, a four lane overpass was constructed over the intersection of State Road 867 (McGregor Boulevard) just east of the bridge.

Florida's statewide SunPass prepaid electronic toll collection system is accepted on the Cape Coral Bridge, along with Lee County's "Leeway" prepaid toll system, which is also used on the Midpoint Bridge, and the Sanibel Causeway.

Due to the age of the 1964 structure, there are currently plans to rebuild the Cape Coral Bridge.