The Cape Girardeau–Jackson Metropolitan Statistical Area, as defined by the United States Census Bureau, is an area consisting of two counties in southeastern Missouri and one in southern Illinois with its core in both states.

It was upgraded from a Micropolitan Statistical Area (μSA) to a Metropolitan Statistical Area (MSA) by the Office of Management and Budget on November 20, 2008.

As of the census[3] of 2000, there were 90,312 people, 35,364 households, and 23,880 families residing within the μSA.

The racial makeup of the μSA was 89.79% White, 7.75% African American, 0.40% Native American, 0.64% Asian, 0.02% Pacific Islander, 0.31% from other races, and 1.09% from two or more races.

Males had a median income of $29,194 versus $19,129 for females.