Prime Minister Jose Neves visited Cape Verdean communities in New England during an official trip to the United States in 2002, and President Pedro Pires visited the United States in April 2005.

The United States provided emergency humanitarian aid and economic assistance to Cape Verde in the period immediately following Cape Verde's independence, as well as after natural disasters, including a hurricane that struck the island of Brava in 1982, and after a severe volcanic eruption on Fogo in 1995.

Cape Verde also is eligible for trade benefits under the African Growth and Opportunity Act (AGOA), and has signed an Open Skies agreement to facilitate air travel safety and expansion.

On July 4, 2005, Cape Verde became the third country to sign a compact with the U.S. Government-funded Millennium Challenge Corporation (MCC); the five-year assistance package is worth over $110 million in addressing rural economic expansion, infrastructure development, and development of the credit sector.

In December 2024, U.S. President Joe Biden paid a visit to Cape Verde and met with Prime Minister Ulisses Correia e Silva and discussed the growing U.S.-Cabo Verdean relationship.