Caposele (Irpino: Capussela) is a town and comune in the province of Avellino, Campania, Italy.

It borders with Calabritto, Bagnoli Irpino, Lioni, Teora, Conza della Campania, Castelnuovo di Conza, Laviano and Valva.

The town, elevation 415m, is reputedly the origin of the Silarius river.

The civil parishes (frazioni) are Buoninventre and Materdomini.

Materdomini was the death place of Gerard Majella; the Basilica of San Gerardo Maiella is dedicated there to him.