In 2011, she was voted in by fans as one of the Top 15 players in Women's National Basketball Association (WNBA) history.

[1][citation needed] Pondexter played for John Marshall Metropolitan High School in Chicago where she was named a WBCA All-American.

She participated in the 2001 WBCA High School All-America Game where she scored sixteen points, and earned MVP honors.

Pondexter took home several awards, including the 2006 Women's Basketball News Service National Player of the year.

[6] In 2007, alongside Diana Taurasi and Penny Taylor, Pondexter played a key role in the Mercury's championship run, and was named 2007 WNBA Finals Most Valuable Player[7] after averaging 22 points per game during the hard-fought five-game series.

[8] At the end of the 2009 season, Pondexter helped the Mercury defeat the Indiana Fever 3 games to 2 to win the WNBA championship,[9] the second title for the team in three years.

When her side's quarter-final match-up against Ros Casares was tied at 67, Pondexter scored the winning basket with just seconds remaining to lift Fenerbahçe to victory.

After successful two seasons at Fenerbahçe, Pondexter signed with the UMMC Ekaterinburg club in the Russian Superleague, where she played during the winters of 2008–09 and 2009–10.

[19] On the international stage, Pondexter was a member of the USA Women's U18 team which won the gold medal at the FIBA Americas Championship in Mar Del Plata, Argentina.

Pondexter scored 11.0 points per game, and helped the USA team to a 6–1 record and the bronze medal.

:[23] In March 2011, Pondexter drew controversy after posting comments on her Twitter account regarding the devastating 2011 Tōhoku earthquake and tsunami in Japan.