James Moore Homestead is an archaeological site in rural Tazewell County, Virginia.

The site is located near Boissevain, and has both colonial and Native American significance.

There was once a palisaded Native village from the Late Woodland period on the site, and it was chosen by James Moore, a local militia captain who was one of Tazewell County's early settlers, as the site of his homestead in 1772.

Sixteen years later (1786) he was killed by a Shawnee party that also took his family prisoner.

This article about a property in Tazewell County, Virginia on the National Register of Historic Places is a stub.