The Captain Jonathan Stone House is a historic residence in the city of Belpre, Ohio, United States.

Built just ten years after Belpre's 1789 establishment on the north bank of the Ohio River, it is the oldest existing building in the city.

As the Belpre region developed, Stone became a leading member of the area's society; he was elected treasurer of Washington County, and he was one of the three commissioners chosen to survey lands for the future Ohio University in Athens to the west.

[2] Stone's house in Belpre is a two-story structure; except for a small wing on the rear northwestern corner, it is a rectangular building.

[2] It is one of four Belpre locations on the Register, along with the Charles Rice Ames House, the Sixth Street Railroad Bridge, and Spencer's Landing.