Caquetá Department (Spanish pronunciation: [kakeˈta]) is a department of Colombia.

Located in the Amazonas region, Caquetá borders with the departments of Cauca and Huila to the west, the department of Meta to the north, the department of Guaviare to the northeast, the department of Vaupés to the east, the departments of Amazonas and Putumayo to the south covering a total area of 88,965 km², the third largest in the country.

Its capital is the city of Florencia.

Amazonas Antioquia Arauca Atlántico Bolívar Boyacá Caldas Caquetá Casanare Cauca Cesar Chocó Córdoba Cundinamarca Guainía Guaviare Huila La Guajira Magdalena Meta Nariño N. Santander Putumayo Quindío Risaralda San Andrés Santander Sucre Tolima Valle del Cauca Vaupés Vichada

Capital district: Bogotá